Olink for neurology applications
Towards a better understanding of neurology and neurological diseases
Testimonials from our neurology customers:
“I am very pleased with the Olink methodology, which has revealed several new biomarkers in the CSF and plasma from patients with multiple sclerosis. It was of particular interest to be able to detect markers in plasma that reflect neuronal damage, including neurofilament light chains.”
Professor Tomas Olsson, Center for Molecular Medicine, Karolinska Hospital, Stockholm.
“The Olink panel provided some directions we wouldn’t have considered previously, and is a very appealing strategy for neuroscience projects hoping to identify novel CSF biomarkers.”
Tom Lanz, Principal Scientist, Pfizer Neuroscience
“Olink’s multiplex immunoassay panels are unique tools for finding new biomarkers and gaining a better understanding of the pathophysiology of diseases, which is something I apply in my own field of pain research.”
Professor Torsten Gordh, Department of Surgical Sciences, Uppsala University
“Protein signatures can improve our understanding of pathophysiology and disease progression, to better predict clinical outcomes and tailor treatments to match individual patient needs. Olink’s panels require such a small volume of material that it is now possible to analyze temporal profiles of multiple biomarkers of complex disease processes that would be very difficult to examine with other techniques.”
Professor Lars Hillered, Department of Neuroscience, Uppsala University
Olink’s offering for neurologists
Protein biomarker panels
Olink currently offers two 92-plex protein biomarker panels that are focused on neuroscience and neurological diseases.
- Olink Target 96 Neurology – offers a mix of established markers (related to processes such as neural development, axon guidance, synaptic function, or specific conditions such as Alzheimer’s disease), as well as some more exploratory proteins with broader roles in processes such as cellular regulation, immunology, development and metabolism. The panel includes an assay for the key neuro-marker, Tau (Microtubule-associated protein tau, MAPT, Uniprot number P10636)
- Olink Target 96 Neuro Exploratory – Complementing our NEUROLOGY panel, this panel offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures in neurology studies, with assays focused on important biological processes such as axon development, neurogenesis and synapse assembly. The panel includes a high-performance assay for the key neuro-marker, Neurofilament light polypeptide (NFL, Uniprot no. P07196), which is an important marker for degenerative neurological diseases and traumatic brain injury.
- Olink Explore 384 Neurology – offers simultaneous analysis of 384 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and Quality Control procedures. This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary Proximity Extension Assay (PEA) technology. The panel panel offers a mix of established markers related to neurobiological processes and neurological diseases (e.g. neural development, axon guidance, synaptic function, or specific conditions such as Alzheimer’s disease), as well as some more exploratory proteins.
Literature
Our Neurology Focus note provides an overview of how Olink’s panels have been used in neurology research and includes several application examples – DOWNLOAD HERE
