The inaccessibility of the brain and the relative scarcity of definitive physical parameters for clinical evaluation represent major challenges when it comes to neurological conditions such as neurodegenerative diseases and chronic pain. A better understanding of the biology and the underlying pathophysiology is also required. It is important to search for better fluid-based biomarkers that give physicians effective decision making tools. There is a need for easily accessible biomarkers that can diagnose and stratify patients as well as signal when patients respond to treatment.
- Unique technology for protein biomarker discovery with unparalleled specificity, high sensitivity and high throughput, using minimal sample volume
- 1 µL for each 96-plex Target panel, or <3 µL for each 384-plex Explore panel depending on the platform used
- A range of compatible sample types such as plasma, serum, CSF, brain tissue lysates and micro-dialysis fluid
- Two 96-plex panels Olink Target panels and one Olink Explore 384-plex panel available offering validated and exploratory biomarkers for neurology research
- A broader library of ~3000 protein assays for larger, exploratory studies (Olink Explore 3072).
Below you can find a few examples of peer-reviewed articles that have used Olink panels in neurology-related studies.
Cuff S, Merola J, Twohih J, et al. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. (2021) Brain Communications, DOI: 10.1093/braincomms/fcaa218
Isung J, Granqvist M, Trepci A, et al. Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects. (2021) Scientific Reports, DOI: 0.1038/s41598-021-81306-4
Ticau S, Sridharan G, Tsour S, et al. Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis. (2021) Neurology, DOI: DOI: 10.1212/WNL.0000000000011090
Begum G, Reddy R, Yakoub K, Belli A, Davies D and Di Pietro V. Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury. (2020) International Journal of Medical Sciences, DOI: 10.3390/ijms21041216
Santaella A, Kuiperij HB, van Rumund A, Esselink R, van Gool A, Bloem B and Verbeek M. Inflammation biomarker discovery in Parkinson’s disease and atypical parkinsonisms. (2020) BMC Neurology, DOI: 10.1186/s12883-020-1608-8
Whelan C, Mattsson N, Nagle M, Vijayaraghavan S, Hyde C, Janelidze S, Stomrud E, Lee J, Fitz L, Samad T, Ramaswamy G, Margolin R, Mälarstig A and Hansson O. Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease. (2019) Acta Neuropathologica Communications, DOI: 10.1186/s40478-019-0795-2