Targeted discovery proteomics in cardiovascular clinical trials


Christopher R. deFilippi, M.D. Vice-Chairman of Academic Affairs at Inova Heart and Vascular Institute


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Different pathophysiologies can trigger heart failure, which is characterized by an early, asymptomatic stage. In this video, Dr. deFilippi describes targeted discovery proteomics studies using various Olink® Target 96 panels to identify protein biomarkers indicative of pre-heart failure that can drive the development of drugs that can interrupt processes leading to heart failure. Olink® PEA technology was also used to study the proteomic changes following treatment with Vericiguat, a medication used to reduce the risk of cardiovascular death and heart failure.

The webinar covers the following points:

  • A review of three previous studies using a targeted proteomics approach to understand heart failure
  • Known biomarkers of malignant Left Ventricular Hypertrophy (LVH) were identified
  • Novel biomarkers of malignant LVH were identified, many of which are involved in cardiac function or the inflammatory process
  • Vericiguat stimulated a unique protein profile compared to placebo controls