• Key proteomics publications from 2020

    Welcome to the first post of the all-new weekly Olink to Science! Our customer survey revealed that you would like to know more about the many publications, research, and other science happening at Olink, therefore this blog aims to do just that: keep you informed on the exciting science taking place with our technology.

    To begin the year ahead, we take a look back at the year that was. In 2020 Olink was used in research spanning well over 150 papers across many different research areas. Below is a summary of the number of papers published for each research category, as well as an example of what we consider to be a key paper (and worth a read!) published in 2020.

    Cardiovascular diseases – 43

    Key paper: Hoogeveen R, Belo Pereira J, Nurmohamed N, et al., Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention, European Heart Journal, DOI: 10.1093/eurheartj/ehaa648.

    Cardiovascular/metabolic diseases – 5

    Key paper: Pang Y, Kartsonaki C, Lv J, et al., Associations of Adiposity, Circulating Protein Biomarkers, and Risk of Major Vascular Diseases, JAMA Circulation, DOI: 10.1001/jamacardio.2020.6041.

    Dermatological diseases – 6

    Key paper: Rojahn T, Vorstandlechner V, Krausgruber T, et al., Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis, Journal of Allergy and Clinical Immunology, DOI: 10.1016/j.jaci.2020.03.041.

    Environmental toxicology – 2

    Key paper: Salihovic S, Lind L, Larsson A and Lind P., Plasma perfluoroalkyls are associated with decreased levels of proteomic inflammatory markers in a cross-sectional study of an elderly population, Environment International, DOI: 10.1016/j.envint.2020.106099.

    Hepatology – 4

    Key paper: Sekyere S, Port K, Deterding K, Cornberg M and Wedemeyer H., Inflammatory patterns in plasma associate with hepatocellular carcinoma development in cured hepatitis C cirrhotic patients, United European Gastroenterology Journal, DOI: 0.1177/2050640620976991.

    Immunological diseases/Immunology – 14

    Key paper: van der Heijden E, Blokland S, Hillen M, et al., Leflunomide–hydroxychloroquine combination therapy in patients with primary Sjögren’s syndrome (RepurpSS-I): a placebo-controlled, double-blinded, randomized clinical trial, The Lancet Rheumatology, DOI: 10.1016/S2665-9913(20)30057-6.

    Immunotherapy – 6

    Key paper: Babačić H, Lehtiö J, Pico de Coaña Y, Pernemalm M and Eriksson H., In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma, Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000204.

    Infectious diseases – 27

    Key paper: Arunachalam P, Wimmers F, Mok C, et al., Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans, Science, DOI: 10.1126/science.abc6261.

    Inflammatory diseases – 15

    Key paper: Kalla R, Adams A, Bergemalm D, et al., Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease, Journal of Crohn’s and Colitis, DOI: 10.1093/ecco-jcc/jjaa230.

    Metabolic diseases – 12

    Key paper: Zanini J, Pietzner M & Langenberg C., Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes, Current Diabetes Reports, DOI: 10.1007/s11892-020-01340-w.

    Nephrology – 4

    Key paper: von Moos S, Segerer S, Davenport A, Sadoune M, Gerritsen K, Pottecher J, Ruschitzka F, Mebazaa A, Arrigo M and Cippà P., Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients, Nephrology Dialysis Transplantation, DOI: 10.1093/ndt/gfz281.

    Neurology – 16

    Key paper: Huang J, Khademi M, Fugger L, et al., Inflammation-related plasma and CSF biomarkers for multiple sclerosis, PNAS, DOI: 10.1073/pnas.1912839117.

    Obstetrics – 3

    Key paper: Hedman A, Lundholm C, Andolf A, et al., Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study, Scientific Reports, DOI: 10.1038/s41598-020-74722-5.

    Oncology – 17

    Key paper: Leandersson P, Åkersson A, Hedenfalk I, Malander S and Borgfeldt C., A multiplex biomarker assay improves the diagnostic performance of HE4 and CA125 in ovarian tumor patients, PLOS ONE, DOI: 10.1371/journal.pone.0240418.

    Ophthalmology – 3

    Key paper: Markasz L, Olsson K-W, Holmström G and Sindelar R., Cluster Analysis of Early Postnatal Biochemical Markers May Predict Development of Retinopathy of Prematurity, Translational Vision Science and Technology, DOI: 10.1167/tvst.9.13.14.

    Other diseases & syndromes – 5

    Key paper: Horati H, Janssens H, Margaroli C, Veltmana M, Stolarczyk M, Kilgoreb M, Chou G, Peng L, Tiddens H, Chandler J, Tirouvanziam R and Scholte B., Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis, Journal of Cystic Fibrosis, DOI: 10.1016/j.jcf.2020.01.010.

    Respiratory disease – 1

    Key paper: Jónsdóttir B, Ziebell Severinsen M, von Wowern F, San Miguel C, Goetze J and Melander O., ST2 Predicts Mortality In Patients With Acute Hypercapnic Respiratory Failure Treated With Noninvasive Positive Pressure Ventilation, International Journal of Chronic Obstructional Pulmonary Disease, DOI: 10.2147/COPD.S211448.

    Technical studies – 4

    Key paper: Raffield L, Dang H, Pratte K, et al., Comparison of Proteomic Assessment Methods in Multiple Cohort Studies, Proteomics, DOI: 10.1002/pmic.201900278.

    Wider proteomics studies – 10

    Key paper: Suhre K, McCarthy M and Schwenk J., Genetics meets proteomics: perspectives for large population-based studies, Nature Reviews Genetics, DOI: 10.1038/s41576-020-0268-2.

    This year is already starting strongly with a total of 5 papers published in the first few weeks of 2021. Expect to hear more about advances in multi-omics, oncology, and Olink technology, as well as the launch of new Olink products, to name but a few.

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    This year is already starting strongly with a total of 5 papers published in the first few weeks of 2021

    Having had an incredibly successful 2020, and with 2021 already off to a great start, there are no limits to what you and Olink can accomplish together. Follow #olinktoscience or subscribe to keep up to date with more Olink science!

    How the proteome behaves in healthy individuals

    Clinical research, Multiomics
    To achieve the goal of precision medicine, not only do different molecular profiles need to be understood in disease populations, but they must also be understood in the context of healthy populations.

    Key proteomics publications from 2020

    Proteomics
    Welcome to the first post of the all-new weekly Olink to Science! Our customer survey revealed that you would like to know more about the many publications, research, and other science happening at Olink, therefore this blog aims to do just that: keep you informed on the exciting science taking place with our technology.

    Protein biomarkers are crucial in early detection of cancer

    Clinical research, Oncology, Protein biomarkers
    A central premise of precision medicine is to identify biomarkers indicative of disease transitions early on. This is especially important in cancer where early treatment intervention could increase a patient’s chance of survival and reduce the probability of cancer recurrence.

    Using PEA and RNA-Seq to study disease pathology

    Clinical research, Proteomics
    The following study illustrates how transcriptomics and proteomics complement one another to clarify the pathology of a complex, and little understood disease. Atopic dermatitis (AD) is the most common chronic skin condition affecting up to 20% of children and 7-10% of adults, depending on the population.

    Olink protein biomarker panel indicates fermented foods fight inflammation

    Inflammation, Proteomics
    Could food be used to fight chronic disease?

    Study identifies proteins involved in immunotherapy response

    Oncology, Proteomics
    'Ultimately, it is all about understanding and treating patients better in the future.'

    Proteins diagnostic of lung cancer up to 5 years before disease onset

    Oncology
    An earlier Olink to Science blog post covered some amazing research that found that certain blood protein biomarkers have the potential to predict cancer up to 3 years before diagnosis. This may also be the case for lung cancer, as detailed in a recent study by Dagnino and her colleagues, where elevated levels of CDCP1 were detected in participants of a cohort who later developed the disease.

    Utilizing proteogenomics technology for novel drug target discovery

    Drug discovery & development
    High-throughput multiplexed proteomic technology is leading the way to the latest developments in pre-clinical disease analysis in drug discovery. The pharmaceutical industry is now increasing its efforts in the discovery of novel drug targets by using protein quantitative trait loci (pQTLs), which allows for a more confident inference of disease causality and associated protein regulation.

    Developing a high-performance biomarker panel for Alzheimer’s disease

    Clinical research, Neurology, Protein biomarkers
    A simple search of the term ‘scourge of Alzheimer’s Disease’ brings up over half a million website hits. A major disease, about 15% of us that reach the age of 67 to 74, and 44% of those 75 to 84 will develop AD.

    How proteomics helped diabetic kidney disease research advance

    Clinical research, Proteomics
    Dr. Krolewski and his team at the Harvard Medical School found 56 proteins to be significant in diabetic kidney disease patients. Potentially, these could serve as prognostic biomarkers for disease progression and treatment response. This is how adding proteomics to the methodologies elevated their research.

    2947

    Biomarker assays

    ~881 million

    Protein data points generated

    1182

    Publications listed on website

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