A protein biomarker risk score to predict overall 5-year survival in ovarian cancer

Background

A study from Uppsala University details the large-scale clinical validation of a previously described 11-protein diagnostic protein profile for ovarian cancer. Validation analysis was performed by measuring over 1100 clinical samples from two independent cohorts using a custom Olink® panel.

Outcome

This validation study confirmed the performance of the multi-protein model they had identified previously, which in this study showed a sensitivity of 0.83/0.91 and specificity of 0.88/0.92 in the two independent cohorts used. Data-driven modeling of the risk score patterns during a two-year follow-up after diagnosis identified four separate risk score trajectories linked to clinical development and survival. Analysis of 5-year survival showed that at time of diagnosis the risk score is the second-strongest predictive variable for survival after tumor stage.

Enroth-et-al-2022

Citation

Enroth S, Ivansson E, Hedlund Lindberg J, et al. Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment. (2022) Communications Medicine, DOI: 10.1038/s43856-022-00193-6

We have shown that the performance of the risk score model is robust across cohorts. Also, the risk score pattern after diagnosis follows the common clinical responses during treatment and relapse/progression and may be useful in monitoring clinical developments during follow-up.

Enroth et al. 2022

Peer-reviewed publications citing the use of Olink panels

Olink’s Proximity Extension Assay (PEA) technology has been used for protein biomarker discovery and analysis across a very broad range of disease areas and applications, providing actionable insights into disease biology and helping to drive future development of new and better therapeutics. There are now well over 1000 publications citing the use of our assays and the list is growing rapidly. Please visit our library of publications to see some of the extraordinary work produced by Olink customers.

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