Customized panels for specific and exclusive studies, with absolute or relative quantification.
To tailor healthcare to individual patients, we need to take the actionable insights gained from protein biomarker discovery and implement them as well-defined protein signatures. Olink® Focus is a custom-made product developed by our in-house research and development experts that enables this implementation.
While our standard offer of Olink® Explore 3072 and Olink® Target 96 panels provides an ideal broad screening-to-targeted discovery solution, our custom panel development enables customers to take the next important steps towards protein biomarker validation and implementation.
How does it work?
When you have defined an informative protein profile from running our Explore or Target panels, we can work with you to design and validate your own Olink Focus panel of up to 21 proteins from the Target and Explore libraries.
Our library covers every major biological pathway and function within the low abundant plasma proteome. We can combine assays that normally require differential sample dilution through “assay optimization”.
Use Olink Focus to move further along the path from early protein biomarker discovery, through to the validation and implementation of clinically relevant protein signatures.
Proximity Extension Assay (PEA) technology
Read more about how Olink technology delivers this scale of multiplexing and sample throughput without compromising on data quality or assay robustness.
Unique 21-plex custom-made panel tailored to customer needs. Combine low- and high-abundant assays into the same panel.
The minimum number of samples you can run per Focus panel is 1000. The number of samples per kit is 144 or 160, depending on absolute or relative quantification.
Using only 1 μL of blood, our platform can generate millions of data points to help you gain actionable insights, fast.
Depending on your needs, your panel can be developed for delivering results in NPX (relative quantification) or pg/mL (absolute quantification).
Cost-effective approach for largescale proteomic studies.
A new Olink Focus panel takes less than 6 months to develop.
Flexibility for fit-for-purpose validation
While Olink already applies thorough validation processes to all of its standard panels, even more stringent validation is included in the Focus offer. This ensures that the panel is fit for purpose for future clinical utility, such as in early phase clinical trials. The figures below overview some of the basic and optional validation steps available.
Development and optimization of a custom panel using existing PEA assays
Theoretical feasibility study including review of protein list, where technical performance and customer prioritization leads to a preliminary panel suggestion
Relative quantification in NPX or Absolute quantification in pg/mL
Selectable degree of validation including analytical sensitivity (LOD, LLOQ, ULOQ, range) and precision (intra-assay and inter-assay CV assessment)
To tailor the panel for your needs, customer samples will be used to optimize the performance of the chosen assays to the sample set
A benchtop system for protein biomarker analysis
Olink® Signature Q100 is a user-friendly instrument for readout of all Olink® Target and Olink® Focus protein biomarker panels. Learn more about this benchtop solution and how to streamline your protein biomarker analysis.
The Olink biomarker assay panels are available with the flexibility to best suit your needs. You can choose whether to purchase the panels as kits and run them in your own lab, send your samples to our experts at Olink or to one of the many Service Providers of Olink® Technology around the world offering sample analysis service.