Association between ultra-processed food consumption and inflammation: insights from the STANISLAS cohort
European Journal of Nutrition, 2025
Xia L., Girerd N., Lamiral Z., Duarte K., Merckle L., Leroy C., Nazare J., Van Den Berghe L., Seconda L., Hoge A., Guillaume M., Laville M., Rossignol P., Boivin J., Wagner S.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Nutritional Science | Pathophysiology | Plasma |  Olink Target 96 |
Abstract
Purpose
High consumption of ultra-processed food (UPF) is associated with an increased risk of developing chronic diseases. Inflammation may be one of the underlying mechanisms behind this association. However, only a limited number of studies have investigated the association between UPF consumption and a few selected inflammation biomarkers, yielding inconsistent results. This study aimed to assess the cross-sectional association between UPF consumption (as a whole and 10 sub-categories), and 78 circulating proteins related to inflammation.
Methods
The present study included 1594 adult participants from the STANISLAS cohort. UPF consumption was estimated using the NOVA classification, and linear regression models were used to assess their association with circulating proteins.
Results
UPFs accounted for 28% of the total energy intake and 5.7 servings on average per day. In the unadjusted model, 15 circulating proteins had a significant association with UPF consumption. After adjustment, only (FGF-19) was significantly associated with UPF consumption (β = − 0.02[− 0.03; − 0.003]).
Conclusion
UPF consumption was negatively associated with Fibroblast Growth Factor 19 (FGF-19) serum levels. When considering UPF sub-categories, no circulating proteins were associated with dairy products and dairy desserts. Of note, circulating proteins were differentially associated depending on the sub-category of UPF. Further studies are needed to better understand the link between UPF and inflammation.