Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality
Tuberculosis, 2020
Koeken V., Ganiem A., Dian S., Ruslami R., Chaidir L., Netea M., Kumar V., Alisjahbana B., van Crevel R., van Laarhoven A.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Infectious Diseases | Pathophysiology | CSF | O Olink Target 96 |
Abstract
Inflammation contributes to the pathophysiology and high mortality of tuberculous meningitis. The IL-1β pathway has been implicated in immunopathology and could be a target for host-directed therapy. IL-1β was elevated in the cerebrospinal fluid (CSF) of 225 HIV-uninfected tuberculous meningitis patients in Indonesia compared to controls, but did not predict subsequent mortality, nor did IL-6 or IL-1Ra. Furthermore, genetic loci known to regulate IL1B gene expression did not predict mortality in 443 tuberculous meningitis patients, although two of these loci did predict CSF IL-1β concentrations. Collectively, these data argue against a role for IL-1β targeted host-directed therapy in tuberculous meningitis.