Circulating HLA-G and its association with cardiovascular markers in pregnancy
Journal of Reproductive Immunology, 2021
Lekva T., Jacobsen D., Sugulle M., Moe K., Fjeldstad H., Dechend R., Staff A.
Disease area | Application area | Sample type | Products |
---|---|---|---|
Immunological & Inflammatory Diseases Obstetrics | Pathophysiology | Plasma | Olink Target 96 |
Abstract
Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation.