Effect of food intake on 92 biomarkers for cardiovascular disease

Digestion of food is known to have significant hemodynamic and metabolic effects, which could potentially affect levels of biomarkers used in CVD studies. The authors decided to look at the effect of food consumption on the markers in the CVD III panel, to flag affected proteins and gather information that could be relevant for blood sample timing, for example. They also considered it to be of physiological interest to investigate biological responses to food intake.

22 healthy caucasian subjects (50% male/female) average age 29.5 yrs and with no history of CVD were used. They were given a standardized 330 kcal meal of 300g rice pudding, with blood sampling taken immediately before, and +30 and +120 minutes after the meal. Of the 91 proteins analyzed (NTproBNP