Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians
Aging Cell, 2025
Plaza‐Florido A., Alejo L., Pérez‐Prieto I., Carrera‐Bastos P., Muñoz M., Aldazabal I., Barranco‐Gil D., Santos‐Lozano A., Rodríguez‐Romo G., Yanguas‐Casás N., Radom‐Aizik S., Lucia A., Fiuza‐Luces C.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Aging | Pathophysiology | Plasma |  Olink Explore 3072/384 |
Abstract
Centenarians exhibit remarkable disease resilience despite chronic low‐grade inflammation. We investigated the inflammation‐related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation‐related pathways.