Exploring the Expression Profiles of Serum Inflammatory Proteins and Potential Antiaging Targets in Chinese Long-Living People

Chronic inflammation (inflammaging) is one of the important reasons for the development of age-related diseases and aging. Carrying out aging research and mining inflammatory markers can develop anti-aging intervention targets, thus promoting healthy aging. By comparing the levels of inflammatory proteome in the serum of Chinese long-living people over 90 years and elderly aged 60~79 which was detected by Olink platform, this study found that some pro-inflammatory or pro-aging proteins increased significantly in the long-living people, such as CXCL9, accompanied by a significant increase in the levels of several anti-inflammatory or anti-aging proteins, including FGF19 and FGF23, which confirmed that compared with elderly people, pro-inflammatory and anti-inflammatory (pro-aging and anti-aging) tend to be balanced in long-living people, thus reducing the risk of age-related diseases and prolonging the life span of the elderly. These differently expressed proteins could serve as therapeutic targets and monitoring indicators for anti-aging. At the same time, a few inflammatory protein markers, especially CXCL9 and OPG, could distinguish long-living and elderly correctly which could be used to predict lifespan combined with other anti-aging markers.