Immunological Serum Protein Profiles for Noninvasive Detection of Acute Cellular Rejection After Heart Transplantation
Journal of the American College of Cardiology, 2017
Sukma Dewi I., Gidlöf O., Hollander Z., Lam K., Benson M., Braun O., Nilsson J., Tebbutt S., Ng R., Öhman J., McManus B., Smith J.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD | Patient Stratification | Plasma |  Olink Target 96 |
Abstract
Acute cellular rejection (ACR), a T-cell-mediated form of organ rejection, remains a common problem after transplantation that compromises long-term allograft survival.We aimed to comprehensively explore immunological protein profiles in heart transplant recipients with ACR in 2 heart transplant cohorts. In this cohort, 10 of the 92 inflammatory proteins were significantly higher in patients with ACR, and 5 of these were independently informative. A multimarker protein score gave significant separation between ACR cases and controls (UAC = 0.82) and was repeated in a validation cohort (AUC = 0.8). The encouraging results from this study motivate a large, prospective study to determine whether plasma biomarkers reflecting T-cell activation can reduce the burden of endomyocardial biopsy in heart transplant recipients.