Olink

Olink®
Part of Thermo Fisher Scientific

Mendelian randomization identifies OX40 as a potential mediator of the effects of cigarette smoking in palmoplantar pustulosis

British Journal of Dermatology, 2025

Smail A., Dand N., Liu X., Burden A., Baudry D., Griffiths C., Pink A., Reynolds N., Warren R., Barker J., Smith C., Capon F., Abraham T., Ali M., August S., Becher G., Bewley A., Brown V., Cooper H., Cornelius V., Dunnil G., Ghaffar S., Ingram J., Kavakleiva S., Kelly S., Khorshid M., Lachmann H., Ladoyanni E., Levell N., McAteer H., McKenna J., Meynell F., Patel P., Parslew R., Powell K., Pushparajah A., Sinclair C., Wachsmuth R., Wahie S., Wright A., Baudry D., Burden A., Griffiths C., Pink A., Reynolds N., Warren R., Visvanathan S., Barker J., Løset M., Smith C., Capon F.

Disease areaApplication areaSample typeProducts
Dermatological Diseases
Pathophysiology
Plasma
Olink Explore 3072/384

Olink Explore 3072/384

Abstract

We used two-step Mendelian randomization to investigate the inflammatory mediators underlying the effects of cigarette smoking on palmoplantar pustulosis (PPP). We first examined the causal effects of smoking on plasma cytokine levels and then those of smoking-associated cytokines on PPP risk. We identified OX40 as potential mediator of the effects of smoking in PPP.

Read publication ↗