Multiomic blood correlates of genetic risk identify presymptomatic disease alterations
Proceedings of the National Academy of Sciences, 2020
Wainberg M., Magis A., Earls J., Lovejoy J., Sinnott-Armstrong N., Omenn G., Hood L., Price N.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Wider Proteomics Studies | Pathophysiology | Plasma |  Olink Target 96 |
Abstract
Most diseases do not develop suddenly, but rather involve the gradual malfunction of physiological processes due to genetic and environmental influences. Here, we study blood measurements from 4,905 individuals and find that people at elevated genetic risk for various diseases have hundreds of detectable changes in blood protein and metabolite levels as well as clinical laboratory tests. These changes tend to also be present in people with the disease, suggesting that they represent early signs of physiological dysfunction occurring before the onset of disease symptoms.