Proteome signature difference between respiratory viruses is associated with severity of bronchiolitis
Pediatric Allergy and Immunology, 2021
Ooka T., Raita Y., Ngo D., Mansbach J., Zhu Z., Camargo C., Hasegawa K.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Infectious Diseases | Pathophysiology | Serum |  Olink Target 96 |
Abstract
Most cases of severe bronchiolitis are caused by two distinct viruses: respiratory syncytial virus (RSV) and rhinovirus (RV). by comprehensively profiling the serum proteome of infants enrolled into a multicenter bronchiolitis cohort, we examined the relationships between respiratory viruses (RSV and RV), circulating proteome, and acute severity of bronchiolitis.
Proteomic profiling assayed a total of 1,109 circulating proteins.Of the 30 proteins significant proteins identified, 17 proteins (eg, VSIG4)are upregulated in the RSV group while 13 proteins (eg, IL-17A,CCL25, MCP-4/CCL13) are upregulated in the RV group.
In conclusion, based on the multicenter prospective data of infants with severe bronchiolitis, we found virus-specific (RSV vs. RV) circulating proteome signatures with biologically relevant inflammatory pathways. Discriminatory proteins were associated with the severity of bronchiolitis. Our data provide additional evidence that the pathobiology of bronchiolitis is heterogeneous and varies by respiratory virus. Our findings should advance research into the complex interrelations between respiratory viruses and host systemic response, as well as their integrated contributions to clinical outcomes in bronchiolitis.