Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections
mBio, 2022
Rosendal E., Mihai I., Becker M., Das D., Frängsmyr L., Persson B., Rankin G., Gröning R., Trygg J., Forsell M., Ankarklev J., Blomberg A., Henriksson J., Överby A., Lenman A.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Infectious Diseases | Pathophysiology | Cell Lysate | O Olink Target 48 |
Abstract
Identification of host factors affecting individual SARS-CoV-2 susceptibility will provide a better understanding of the large variations in disease severity and will identify potential factors that can be used, or targeted, in antiviral drug development. With the use of an advanced lung cell model established from several human donors, we identified cellular protease inhibitors, serpins, as host factors that restrict SARS-CoV-2 infection.