The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid
Cytokine, 2015
Larsson A., Carlsson L., Lind A., Gordh T., Bodolea C., Kamali-Moghaddam M., Thulin M.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Wider Proteomics Studies | Epidemiology | CSF |  Olink Target 96 |
Abstract
The aim of the study was to investigate the effects of body mass index (BMI) and age on cytokine and chemokine levels in cerebrospinal fluid (CSF). No significant correlations between age and cytokine levels for any of the studied markers were found, but 19 markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1). There is a clear effect of BMI on cytokine and chemokine levels in cerebrospinal fluid, therefore data should be adjusted for BMI when comparing CSF cytokine values between patients and controls.