Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study
Journal of Applied Physiology, 2023
Aizawa K., Gates P., Mawson D., Casanova F., Gooding K., Hope S., Goncalves I., Nilsson J., Khan F., Colhoun H., Natali A., Palombo C., Shore A.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Metabolic Diseases CVD | Pathophysiology | Plasma | O Olink Target 96 |
Abstract
We demonstrate in this study a greater BP-independent arterial stiffness β0 in people with type 2 diabetes (T2DM) compared to those without, and also a greater change in β0 over 3 yr in people with T2DM than those without. These findings suggest that the intrinsic properties of the arterial wall may change in a different and more detrimental way in people with T2DM and likely represents accumulation of cardiovascular risk.