Comorbid diabetes disease severity and microbial changes in patients with bronchiectasis: a combined analysis of data from the EMBARC, EMBARC-India, Australian, and BE-China registries
The Lancet Respiratory Medicine, 2026
Hull R., Liu Y., Cao Z., Xuan K., de Lima Headley D., Richardson H., Hennayake C., Lind H., McIntosh E., Pollock J., Hughes C., Viligorska K., Choi H., Gao Y., Chotirmall S., Shoemark A., Robertson K., Burgel P., Vendrell M., Xu X., Qu J., Song Y., Guan W., Chen R., Singh S., Talwar D., Mohan B., Tripathi S., Swarnakar R., Trivedi S., Goeminne P., Shteinberg M., De Soyza A., Altenburg J., Haworth C., Sibila O., Polverino E., Loebinger M., Ringshausen F., Mertsch P., Lorent N., Dimakou K., Mendez R., Mclaughlin A., Borrill Z., Lord R., Finch S., Blasi F., Burr L., Crisafulli M., Keating R., Middleton P., Long M., Aliberti S., Morgan L., Dhar R., Chalmers J., Xu J.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Metabolic Diseases Respiratory Diseases | Pathophysiology | Serum |  Olink Target 96  Olink Explore 3072/384 |
Abstract
Background
Bronchiectasis and diabetes commonly coexist and are associated with immune dysfunction and increased susceptibility to infection. Although diabetes is associated with worse prognosis in cystic fibrosis-related bronchiectasis, data are scarce for its impact on non-cystic fibrosis bronchiectasis. This study aimed to characterise the impact of diabetes on clinical outcomes and microbial and inflammatory profiles in patients with bronchiectasis.
Methods
This analysis comprised data from the European Bronchiectasis Registry (EMBARC), Respiratory Research Network of India (EMBARC-India), Chinese Bronchiectasis Registry (BE-China), and Australian Bronchiectasis Registry (ABR); 30 263 patients with CT-confirmed bronchiectasis in 33 countries were included in the analysis: 16 963 from EMBARC (Jan 12, 2015, to April 12, 2022), 2361 from EMBARC-India plus additional Asian countries (June 1, 2015, to Sept 1, 2017), 10 324 from BE-China (Jan 10, 2020, to March 31, 2024), and 615 from the ABR (March 7, 2016, to Sept 11, 2018). Clinical data were compared between patients with and without diabetes. Long-term outcome data were available in EMBARC and EMBARC-India. Microbiome and inflammatory profiles were characterised in a sub-cohort of EMBARC patients by sputum 16S rRNA sequencing (n=433) and serum Olink (n=479).
Findings
2487 (8·2%) of 30 263 patients with bronchiectasis had diabetes. Patients with diabetes had a higher prevalence of comorbidities than those without diabetes, including cardiovascular disorders (53·5% vs 21·8%, p<0·0001), asthma (27·5% vs 21·0%, p<0·0001), and chronic obstructive pulmonary disease (34·3% vs 19·0%, p<0·0001). Patients with diabetes had more severe disease than those without diabetes, with higher Bronchiectasis Severity Index scores (8 [IQR 5–12] vs 7 [4–10], p<0·0001) and UK Medical Research Council (MRC) dyspnoea scores (p<0·0001) and more hospital admissions in the previous year (p<0·0001). After adjustment for confounders, outcomes were significantly worse in patients with diabetes than in those without diabetes, including more frequent exacerbations (incidence rate ratio [IRR] 1·18 [95% CI 1·09–1·28], p<0·0001), hospital admissions (IRR 1·57 [1·40–1·76], p<0·0001), and higher 5-year mortality (hazard ratio 1·80 [1·53–2·12], p<0·0001). The sputum microbiome was significantly altered in patients with diabetes compared to those without diabetes, with increased isolation of Enterobacteriaceae (p<0·0001), Moraxella catarrhalis (p=0·0035), and Haemophilus influenzae (p=0·046). In serum, Gal-4 and GDF-15, established biomarkers of disease severity and cardiovascular risk in diabetes, were significantly increased in patients with diabetes (Gal-4, p<0·0001; GDF-15, p=0·0019).InterpretationPatients with diabetes and bronchiectasis are a high-risk population with more severe disease, worse outcomes, increased comorbidities, and increased risk of infections compared with patients without diabetes. These findings support inclusion of diabetes as a risk factor in individualised risk assessments for bronchiectasis.