Olink

Olink®
Part of Thermo Fisher Scientific

Key messages
Why neurobiology needs deeper protein insights

Protein biomarkers are central to translational and clinical neurobiology research. Yet, many established neurological biomarkers only capture a partial picture of biology driving neurological processes and diseases, especially when used in isolation. High-specificity proteomics can help you explore new protein signatures and patterns with translational potential.

Disease biology

Explore protein patterns associated with neurodegeneration, neuroinflammation, psychiatric disorders, and more.

Pathway insights

Investigate the complex pathways governing neurological signaling, glial activation, neurogenesis, and other key processes.

Emerging biomarkers

Discover multi-protein signatures and investigate their potential for diagnosis, monitoring, and stratification in clinical research.

Population variation

Investigate how individual heterogeneity may help to influence disease processes and potentially treatment responses.

Research approach
How Olink proteomics supports neurological biomarker research

Progress in neurological biomarker research depends on moving beyond established CNS biomarkers towards a broader systems-biology view, supported by technology that delivers specificity, sensitivity, scalability, and reproducibility. Olink helps you explore neurobiology with exceptional biological breadth and depth, measure low abundance signals in blood and cerebral spinal fluid (CSF), and move from discovery toward translational follow-up all with the same technology platform.

Research need

How Olink proteomics supports it

Reveal more neurobiology

Broad proteomic coverage enables exploration of pathways beyond established neurological biomarkers.

Measure with confidence

High specificity and sensitivity support reliable detection of low-abundance biomarkers across plasma, CSF, and beyond from as little as 1 μL of sample.

Scale without compromise

The Olink platform supports large-scale biomarker discovery, focused biomarker follow-up, and cohort-based translational research with robust data quality and throughout.

Build on evidence

Compare new findings against existing population-scale proteomics datasets and annotations to strengthen biological evidence and guide follow-up research.

Simplified integration

Get started easily with assays that fit into existing workflows.

Support

Leverage Olink experts or global Service Providers to help ensure your study’s success.

Topic deep dives
How researchers are using Olink proteomics to advance their neurology research

From uncovering complex disease biology and early drivers of neurological disease to identifying emerging biomarker candidates and generating real-world evidence, explore how researchers are using Olink solutions to push the boundaries of neurological research.

Read the white paper from this webinar

Informed by a roundtable discussion with leading experts from academia and biopharma, this white paper examines what is working, what remains challenging, and the practical lessons learned in applying biomarker research to advance precision approaches in neurology.

    Testimonials

    Voices from the neurological biomarker research community

    Hear from researchers using Olink solutions to advance their neurobiology research across neurodegeneration, dementia, and translational programs.

    The Target 48 Neurodegeneration is a critical tool that enables the detection and quantification of key and emerging neurodegenerative biomarkers from plasma and cerebrospinal fluid samples. By generating quantitative data, it ensures reproducible results across and within longitudinal studies, moving a step forward towards potential clinical utilization.

    Charlotte Teunissen

    Professor in neurochemistry, Department of Laboratory Medicine, Amsterdam University Medical Center

    Molecular subtyping—enabled by platforms such as the Olink Explore HT panel—has begun to reveal biologically meaningful subgroups within AD. These insights may help explain clinical variability and guide more targeted therapeutic strategies.

    Pallavi Sachdev, MPH, PhD

    Executive Director and Head, Translational Medicine, Eisai Inc.

    Combining the Olink Target 48 Neurodegeneration and Target 48 Cytokine panels allowed us to quantify 86 biomarkers relevant to neurodegeneration and the immune response. The unified workflow of these panels offers a practical, cost-effective way to generate highly reproducible pg/mL data, supporting our study of chronic inflammation and neurocognitive impairment risk in HIV patients receiving antiviral therapy.

    Daniel Kaufman

    Clinical researcher and physician, Chief of Division of Infectious Diseases at the Lausanne University Hospital

    Using the Olink Target 48 Neurodegeneration panel in our Parkinson’s disease research allowed us to interrogate key neurodegenerative pathways with a level of sensitivity and reproducibility that is difficult to achieve in plasma. The panel captured biologically meaningful changes in proteins across sporadic and LRRK2 PD participants and is a powerful tool for studying PD pathophysiology.

    Ferhan Qureshi

    SVP Biomarker R&D, Octave Bioscience, Inc.

      Selected reading
      Selected reading in neurobiology research

      Explore recent discoveries and emerging advances in neurological biomarker research—from large-scale proteomics studies and novel disease insights to the translational applications that have the potential to shape the future of neurology.

      Resources
      Documents

      Below are a few documents highlighting how PEA technology is being applied to tackle the complexity of neurological disease research.

      DocumentsTypeFile
      Insights from precious samples in neurology research
      Flyer
      Download PDF
      Performance of Olink® Explore 3072 in Brain Tissue Lysates technical note
      Technical note
      Download PDF
      Multiomics at the Frontline of Neurology Research
      Customer interview
      Download PDF
      Emerging Dementia Biofluid Biomarker Candidates Identified in Human Proteomic Studies (2021-2025)
      Data resource
      Download PDF
      Product portfolio
      A flexible platform that accelerates your research

      Olink’s scalable technology provides optimized solutions for every stage of the biomarker workflow, from high-throughput discovery through validation and clinical utility.

      Olink Explore HT

      Measure 5,400+ proteins with proven specificity to gain an understanding of disease at the protein level.

      Proteins

      5,400+With proven specificity

      Sample

      2 µLPlasma, serum & more

      Olink Flex

      Run individually tailored studies by combining up to 30 biomarkers from our extensive library with minimal sample volume.

      Proteins

      ~200Pre-validated assays

      Sample

      1 µLPlasma, serum & more

      Olink Target 96 icon.

      Olink Target 96

      Target specific disease areas or key biological processes with multiplex immunoassay panels.

      Proteins

      9211 targeted panels

      Sample

      1 µLPlasma, serum & more

      Olink Target 48

      Extensively validated and carefully selected biomarkers for a comprehensive view of immune and neurodegeneration processes.

      Proteins

      up to 453 panels

      Sample

      1 µLPlasma, serum & more

      Access options
      Bringing PEA technology into your research

      Whether you are looking for full-service sample analysis, support from a Certified Service Provider, or want to run the assays in your own lab, you can access Olink solutions in a way that fits your study designs and infrastructure needs.