Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study
The Journal of Pediatrics, 2024
Thomson L., Niemiec S., Mancuso C., Khailova L., Ali E., Syed A., Wolfe K., Zakrzewski J., Stone M., Hyslop R., Frank B., Davidson J.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD Pediatrics | Patient Stratification | Plasma | O Olink Explore 3072/384 |
Abstract
This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving post-operative extracorporeal membrane oxygenation (ECMO) support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor ECMO outcomes.