Human immune system variation

Review article looking at variation in the human immune system, and how technological advances are beginning to provide more insights. The basic view is that the immune system varies greatly between individuals, but is quite stable over time for any given individual. It also looks at how new technologies are providing a better picture of the compositions of immune cells and proteins in populations of healthy individuals. While there certainly are genetic factors involved, they conclude that most of the variation observed is due to non-heritable factors such as the bacterial fauna, exposure to viruses and multiple environmental factors including smoking. Olink is mentioned as one of the key new technologies for analyzing immune-system protein variations.