Low Elastin Content of Carotid Plaques Is Associated with Increased Risk of Ipsilateral Stroke
PLOS ONE, 2015
Asciutto G., Dias N., Edsfeldt A., Nitulescu M., Persson A., Nilsson M., Dunér P., Nilsson J., Gonçalves I.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD Neurology | Patient Stratification | Blood |  Olink Target 96 |
Abstract
The aim of this study was to see whether the content of collagen, elastin and MMP-1.-3,-9 and 12 in plaques can be associated with higher risk for stroke. Proseek Multiplex was used to analyze MMP-12, other techniques were used to analyze collagen, elastin and the other MMP’s (e.g. the MMP’s were analyzed using the Mesoscale human MMP ultrasensitive kit). Results of this study shows that MMP-12, MMP-3 and elastin levels are low in plaque, elastin seems important for plaque stability, and low plaque content of elastin is associated with a higher risk for stroke.