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Low Elastin Content of Carotid Plaques Is Associated with Increased Risk of Ipsilateral Stroke

PLOS ONE, 2015

Asciutto G., Dias N., Edsfeldt A., Nitulescu M., Persson A., Nilsson M., Dunér P., Nilsson J., Gonçalves I.

Disease areaApplication areaSample typeProducts
CVD
Neurology
Patient Stratification
Blood
Olink Target 96

Olink Target 96

Abstract

The aim of this study was to see whether the content of collagen, elastin and MMP-1.-3,-9 and 12 in plaques can be associated with higher risk for stroke. Proseek Multiplex was used to analyze MMP-12, other techniques were used to analyze collagen, elastin and the other MMP’s (e.g. the MMP’s were analyzed using the Mesoscale human MMP ultrasensitive kit). Results of this study shows that MMP-12, MMP-3 and elastin levels are low in plaque, elastin seems important for plaque stability, and low plaque content of elastin is associated with a higher risk for stroke.

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