Microvesicles in plasma reflect coronary flow reserve in patients with cardiovascular disease
American Journal of Physiology-Heart and Circulatory Physiology, 2021
Bryl-Górecka P., James K., Torngren K., Haraldsson I., Gan L., Svedlund S., Olde B., Laurell T., Omerovic E., Erlinge D.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD | Technical Evaluation | EV Lysate | O Olink Target 96 |
Abstract
We investigated how microvesicles (MVs) from patients with cardiovascular diseases are related to coronary flow reserve (CFR), a clinical parameter reflecting blood flow in the heart. Our results show a negative relationship between CFR and levels of platelet and endothelial MVs. The pattern of MV-enriched cardiovascular biomarkers differs between patients with high and low CFR. Our findings suggest a potential clinical value of MVs as biomarkers of reduced blood flow and proatherogenic status, additional to CFR.