Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis
Atherosclerosis, 2015
Lind L., Ärnlöv J., Lindahl B., Siegbahn A., Sundström J., Ingelsson E.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD | Patient Stratification | Plasma |  Olink Target 96 |
Abstract
The plasma levels of 82 proteins were studied in relation to plaque prevalence in carotid arteries from 931 senior men and women, all aged 70 years. Seven proteins were significantly associated with the severity of carotid plaques (OPG, TIM-1, GDF-15, MMP-12, REN, TNFSF14 and GH). Of these, REN, GH, OPG and TNFSF14 were were related to plaque prevalence independently of each other and traditional cardiovascular risk factors.