Explore HT
Gene
CLEC4M
Uniprot
Q9H2X3
Protein
C-type lectin domain family 4 member M
See alternative names Liver/lymph node-specific ICAM-3-grabbing non-integrin,
Dendritic cell-specific ICAM-3-grabbing non-integrin 2,
DC-SIGN-related protein,
CD209 antigen-like protein 1
Uniprot Function Description
(Microbial infection) Acts as an attachment receptor for Influenzavirus.
(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.
(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
(Microbial infection) Acts as an attachment receptor for West-nile virus.
(Microbial infection) Acts as an attachment receptor for SARS-CoV.
(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.
(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.
(Microbial infection) Acts as an attachment receptor for HIV-1.
(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
Sample type
Recommended sample types are human plasma and serum. For other sample types e.g cerebrospinal fluid, (CSF), tissue or cell lysate, please contact support@olink.com for more information. Please note that protein expression levels are expected to vary in different sample types and certain assays may be affected by interfering substances such as hemolysate.
Precision
Precision (repeatability) is calculated from linearized NPX values over LOD.
Analytical measuring range
The technical data reported below refers to the measured value in the in vitro validation assays run using known concentrations of recombinant antigen.
Dilution factor
For optimal assay readout, Olink assays are run using different dilutions of the original samples e.g. undiluted, 1:10, or higher. The dilution factor for this assay is noted below and should be taken into account when estimating the appropriate addressable biological concentration of the protein based on the in vitro validation data.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center