Explore HT
Gene
CXCL8
Uniprot
P10145
Protein
Interleukin-8
See alternative names IL8/NAP1 form II,
(Ala-IL-8)77,
IL8/NAP1 form I,
GCP/IL-8 protein IV,
T-cell chemotactic factor,
Neutrophil-activating protein 1,
Monocyte-derived neutrophil-activating peptide,
Monocyte-derived neutrophil chemotactic factor,
Protein 3-10C,
MDNCF-b,
(Ser-IL-8)72,
GCP/IL-8 protein I,
IL8/NAP1 form III,
Lymphocyte-derived neutrophil-activating factor,
MDNCF-c,
Neutrophil-activating factor,
GCP/IL-8 protein V,
IL8/NAP1 form IV,
GCP/IL-8 protein VI,
IL8/NAP1 form V,
GCP/IL-8 protein III,
IL8/NAP1 form VI,
GCP/IL-8 protein II,
Chemokine (C-X-C motif) ligand 8,
C-X-C motif chemokine 8,
IL-8(1-77),
Granulocyte chemotactic protein 1,
Emoctakin
Uniprot Function Description
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Sample type
Recommended sample types are human plasma and serum. For other sample types e.g cerebrospinal fluid, (CSF), tissue or cell lysate, please contact support@olink.com for more information. Please note that protein expression levels are expected to vary in different sample types and certain assays may be affected by interfering substances such as hemolysate.
Precision
Precision (repeatability) is calculated from linearized NPX values over LOD.
Analytical measuring range
The technical data reported below refers to the measured value in the in vitro validation assays run using known concentrations of recombinant antigen.
Dilution factor
For optimal assay readout, Olink assays are run using different dilutions of the original samples e.g. undiluted, 1:10, or higher. The dilution factor for this assay is noted below and should be taken into account when estimating the appropriate addressable biological concentration of the protein based on the in vitro validation data.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center