Target 48 Cytokine
Gene
CXCL8
Uniprot
P10145
Protein
Interleukin-8
See alternative names IL8/NAP1 form II,
(Ala-IL-8)77,
IL8/NAP1 form I,
GCP/IL-8 protein IV,
T-cell chemotactic factor,
Neutrophil-activating protein 1,
Monocyte-derived neutrophil-activating peptide,
Monocyte-derived neutrophil chemotactic factor,
Protein 3-10C,
MDNCF-b,
(Ser-IL-8)72,
GCP/IL-8 protein I,
IL8/NAP1 form III,
Lymphocyte-derived neutrophil-activating factor,
MDNCF-c,
Neutrophil-activating factor,
GCP/IL-8 protein V,
IL8/NAP1 form IV,
GCP/IL-8 protein VI,
IL8/NAP1 form V,
GCP/IL-8 protein III,
IL8/NAP1 form VI,
GCP/IL-8 protein II,
Chemokine (C-X-C motif) ligand 8,
C-X-C motif chemokine 8,
IL-8(1-77),
Granulocyte chemotactic protein 1,
Emoctakin
Uniprot Function Description
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Sample type
Recommended sample types are plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsies, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary between different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact support@olink.com for more information.
Precision
Precision (repeatability) is calculated from quantified data (pg/mL) within the limits of quantification: LOQ.
Analytical measuring range
The technical data reported below refers to the measured values generated during the assay validation process using recombinant antigens. Per default, Olink Target 48 products deliver data in absolute protein concentrations (pg/mL) using the Calibrator built into the system.
Sensitivity plot
The calibrator curve shown below visualizes the analytical measuring range determined during the validation process using recombinant antigen. Please note that this is shown for reference only and CANNOT be used to e.g. convert NPX values to absolute concentrations. The vertical dotted lines represent lower limit of quantification (LLOQ) and upper limit of quantification (ULOQ) respectively. The solid horizontal line indicates the limit of detection (LOD).
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center