Characterization of a robust mouse model of heart failure with preserved ejection fraction
American Journal of Physiology-Heart and Circulatory Physiology, 2023
Matsiukevich D., Kovacs A., Li T., Kokkonen-Simon K., Matkovich S., Oladipupo S., Ornitz D.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD | Pathophysiology | Serum |  Olink Target 96 Mouse |
Abstract
Heart failure with preserved ejection fraction (HFpEF) is an emerging epidemic affecting up to half of patients with heart failure. Here we used a chronic angiotensin II/phenylephrine (ANG II/PE) infusion model and instituted an updated algorithm for HFpEF assessment. Given the simplicity in generating this model, it may become a useful tool for investigating pathogenic mechanisms, identification of diagnostic markers, and for drug discovery aimed at both prevention and treatment of HFpEF.