Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Proceedings of the National Academy of Sciences, 2021
Kvedaraite E., Hertwig L., Sinha I., Ponzetta A., Hed Myrberg I., Lourda M., Dzidic M., Akber M., Klingström J., Folkesson E., Muvva J., Chen P., Gredmark-Russ S., Brighenti S., Norrby-Teglund A., Eriksson L., Rooyackers O., Aleman S., Strålin K., Ljunggren H., Ginhoux F., Björkström N., Henter J., Svensson M., Sandberg J., Bergsten H., Björkström N., Brighenti S., Buggert M., Butrym M., Chambers B., Chen P., Cornillet M., Cuapio A., Lozano I., Dzidic M., Emgård J., Flodström-Tullberg M., Gorin J., Gredmark-Russ S., Haroun-Izquierdo A., Hertwig L., Kalsum S., Klingström J., Kokkinou E., Kvedaraite E., Ljunggren H., Marquardt N., Lourda M., Maleki K., Malmberg K., Michaëlsson J., Mjösberg J., Moll K., Muvva J., Norrby-Teglund A., Medina L., Parrot T., Radler L., Ringqvist E., Sandberg J., Sekine T., Soini T., Svensson M., Tynell J., von Kries A., Wullimann D., Perez-Potti A., Rivera-Ballesteros O., Maucourant C., Varnaite R., Akber M., Berglin L., Brownlie D., Loreti M., Sohlberg E., Kammann T., Henriksson E., Strålin K., Aleman S., Sönnerborg A., Dillner L., Färnert A., Glans H., Nauclér P., Rooyackers O., Mårtensson J., Eriksson L., Persson B., Grip J., Unge C.,
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Infectious Diseases | Pathophysiology | Plasma |  Olink Target 96 |
Abstract
While broad efforts toward getting an overview of immune cell and soluble factor alterations in COVID-19 are under way, a deep and comprehensive understanding of the mononuclear phagocyte system, including circulating progenitors, is still largely lacking. This study provides a reference for the mononuclear phagocyte response to SARS-CoV-2 infection and unravels mononuclear phagocyte dysregulations associated with severe COVID-19.