Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk
Nature Communications, 2025
Zalesky A., Tian Y., Ferrucci L., Walker K., Bai W., Rafii M., Aisen P., Anagnostakis F., Ko S., Saadatinia M., Wang J., Davatzikos C., Wen J.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
CVD Aging | Pathophysiology | Plasma |  Olink Explore 3072/384 |
Abstract
Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based biological age gaps (MetBAGs) using 107 plasma non-derivatized metabolites from 274,247 UK Biobank participants. Our age prediction models achieve a mean absolute error of approximately 6 years (0.25