Proteomic Characterization of Grade <scp>II</scp> Furcation Defects: A Discovery‐Phase Study

This study analyzed the gingival crevicular fluid (GCF) proteome of 35 patients with Grade II furcation defects using the Olink Reveal platform. Comparison with non-periodontitis sites identified 227 differentially expressed proteins. A machine-learning pipeline prioritized a 34-protein signature (including GLIPR1, MME, and IRAG2) that accurately differentiated furcation defects from health (AUC = 0.887), reflecting a distinct profile of severe inflammation and neutrophil activation. (Letter format article – description from graphical abstract).