The effects of age and gender on plasma levels of 63 cytokines
Journal of Immunological Methods, 2015
Larsson A., Carlsson L., Gordh T., Lind A., Thulin M., Kamali-Moghaddam M.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Wider Proteomics Studies | Epidemiology | Plasma |  Olink Target 96 |
Abstract
This study reveals the effects of age and gender on a large number of biomarkers. Plasma samples were collected from 33 healthy blood donors. The plasma level of three of the investigated biomarkers (DNER, MCP-4 and MMP-10) were found to be significantly different for the two genders, and 15 of the biomarkers (CCL11, CCL25, CDCP1, CSF-1, CXCL11, CXCL9, FGF-23, Flt3L, HGF, IL-10RB, MCP-3, MCP-4, MMP-10, OPG, VEGF-A) were significantly associated with age. CXCL5 and TNFB were significantly higher in females, while the other markers with significant gender-dependent differences were higher in males. For the markers that were significantly associated with age, only CXCL6 was found to decrease with age, while the other biomarkers increased with age.