The inflammatory proteome, obesity, and medical weight loss and regain in humans
Obesity, 2022
Perry A., Tanriverdi K., Risitano A., Hwang S., Murthy V., Nayor M., Zhao S., Levy D., Shah R., Freedman J.
| Disease area | Application area | Sample type | Products |
|---|---|---|---|
Metabolic Diseases | Pathophysiology | Plasma |  Olink Target 96  Olink Explore 3072/384 |
Abstract
Objective
Weight regain occurs after medical weight loss via mechanisms of post‐weight‐loss “metabolic adaptation.” The relationship of inflammatory proteins with weight loss/regain was studied to determine a role for inflammation in metabolic adaptation.
Methods
Seventy‐four proteins central to inflammation and immune regulation (Olink) were analyzed in plasma from up to 490 participants in a trial of medical weight‐loss maintenance. Cross‐sectional and longitudinal associations of proteins with weight were measured using linear and mixed effects regression models and t testing, with replication in the Framingham Heart Study.
Results
Broad changes in the inflammatory proteome were observed among the study cohort (60% women, 35% African American) with initial weight loss of ≈8 kg from a median 94 kg at study entry (33/74 proteins; 7 increased; 26 decreased), many of which tracked with weight regain of median ≈2 kg over the next 30 months. Ten proteins were associated with different rates of weight regain, some specifying pathways of chemotaxis and innate immune responses. Several of the observed protein associations were also linked to prevalent obesity in the Framingham Heart Study.
Conclusions
Broad changes in the inflammatory proteome track with changes in weight and may identify specific pathways that modify patterns of weight regain.
image